Resveratrol is an anti-estrogen Resveratrol, a compound in the skin of red grapes, has an anti-oestrogenic effect. According to a 2006 test-tube study by the Chinese University of Hong Kong, the effect is so strong that supplementation of high but not impossible doses can protect women against breast cancer. And it can help athletes to lower their estradiol levels, we add ourselves. Study The researchers experimented with the human breast cancer cell SK-BR-3 and the genetically altered MCF-7aro cell. MCF-7 is also originally a human breast cancer cell. The researchers used a version of that cell into which researchers had stuck extra genes, so that the cell started producing aromatase. Aromatase is the enzyme that turns testosterone and androstenedione into estradiol. The relationship between estradiol and cancer is twofold. Estradiol can turn into 4- and 16-hydroxy analogs, which can turn healthy cells into cancer cells. In addition, many breast cancer cells have receptors for
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Alpha-Ketoglutarate dietary supplementation to improve health in humans
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Alpha-Ketoglutarate dietary supplementation to improve health in humans Bibek Gyanwali , 1,2 Zi Xiang Lim, 1,2 Janjira Soh, 3 Clarissa Lim, 1,4 Shou Ping Guan, 1,2 Jorming Goh, 1,3,4 Andrea B. Maier, 1,3,5,6 and Brian K. Kennedy 1,2,3,4,7,* Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in vari- ous metabolic and cellular pathways. As an antioxidant, AKG interferes in nitro- gen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few stud- ies published in the 1980s and 1990s in humans suggested the potential benefits of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in hum
AKG increases lifespan
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Ca-AKG increase lifespan Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in vari- ous metabolic and cellular pathways. As an antioxidant, AKG interferes in nitro- gen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few stud- ies published in the 1980s and 1990s in humans suggested the potential benefits of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in humans.
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Ca-AKG for dogs. Dogs are more prone to toxins and today’s environmental pollution, therefore are having even more issues than humans, related to aging, inflammation, allergies, cellular aging, decreased nutrient sensing, genomic instability, early senescence, epigenetic deterioration and of course, most importantly, NAD+ and ketone derivative glutaric acid depletion. As a professional certified healthcare and a bio-hacker, involved in an aging dimension, been working with Harvard medical schools of epigenetics, I know how important can the Krebs Cycle stability be, having a pivotal role in modulating the major signaling pathways that influence the longevity of organisms. Thus, using a powerful precursor and intermediary metabolite activator for preventing age related diseases and premature deterioration is expected to be able to attenuate the process of aging and greatly ameliorate its effects. Tackling aging is a challenge for any living organism, and longevity
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What is Ca-Akg ? Ca-AKG is the abbreviation of Calcium Alpha-Ketoglutarate (C5H4CaO5-H2O). It is a special form mineral calcium that can be used to bring the calcium concentration in the blood back to a normal level. Calcium alpha-ketoglutarate binds excess phosphate and disposes it as waste, restoring the normal balance of calcium and phosphate in the body. Ca-AKG has been proven to increase lifespan and health span (healthy age-ing without symptoms). AKG is a key metabolite in the KREBS (energy) cycle and plays a role in metabolism, stem cell growth, collagen synthesis and epigenetic regulation. As with many other important health traits, AKG levels decline with age. It has been proven that your AKG levels at 80 are only 10% of when you were 40! AKG cannot be increased through your diet. Ca-Akg benefits Studies have shown it can help with weight gain Ca-AKG can can convert white unhealthy fat into brown fat Can extend a healthy lifespan Can reduce inflammation by re
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Calcium alpha-ketoglutarate extends lifespan and compresses morbidity in aging mice As we age, our metabolism—all the chemical reactions that keep our bodies alive—doesn't work as well as when we were younger. Our bodies don't get nutrients from food and don't convert them as efficiently into energy and the building blocks of our cells. As we age, the levels of many compounds in our bodies also change, such as those for alpha-ketoglutarate (AKG). This important metabolite has been reported to extend the lifespan of both worms and flies and acts as an antioxidant in mammalian cells. But its role in aging and longevity in mice, let alone humans, is relatively unknown. Shahmirzadi and colleagues report that a diet supplemented with Ca-AKG extends the lifespan of middle-aged female mice and improves health in both sexes. With the simultaneous reduction in frailty and an increase in longevity and reduced morbidity. Calcium alpha-ketoglutarate exerts these effects in part by s