Calcium alpha-ketoglutarate extends lifespan and reduces morbidity in aging mice

Alpha-Ketoglutarate dietary supplementation to improve health in humans Bibek Gyanwali , 1,2 Zi Xiang Lim, 1,2 Janjira Soh, 3 Clarissa Lim, 1,4 Shou Ping Guan, 1,2 Jorming Goh, 1,3,4 Andrea B. Maier, 1,3,5,6 and Brian K. Kennedy 1,2,3,4,7,* Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in vari- ous metabolic and cellular pathways. As an antioxidant, AKG interferes in nitro- gen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few stud- ies published in the 1980s and 1990s in humans suggested the potential benefits of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in hum

Ca-AKG increase lifespan Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in vari- ous metabolic and cellular pathways. As an antioxidant, AKG interferes in nitro- gen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few stud- ies published in the 1980s and 1990s in humans suggested the potential benefits of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in humans.

Ca-AKG for dogs.  Dogs are more prone to toxins and today’s environmental pollution, therefore are having even more issues than humans, related to aging, inflammation, allergies, cellular aging, decreased nutrient sensing, genomic instability, early senescence, epigenetic deterioration and of course, most importantly, NAD+ and ketone derivative glutaric acid depletion.   As a professional certified healthcare and a bio-hacker, involved in an aging dimension, been working with Harvard medical schools of epigenetics, I know how important can the Krebs Cycle stability be, having a pivotal role in modulating the major signaling pathways that influence the longevity of organisms. Thus, using a powerful precursor and intermediary metabolite activator for preventing age related diseases and premature deterioration is expected to be able to attenuate the process of aging and greatly ameliorate its effects.    Tackling aging is a challenge for any living organism, and longevity