Ca-AKG for dogs.
Dogs are more prone to toxins and today’s environmental pollution, therefore are having even more issues than humans, related to aging, inflammation, allergies, cellular aging, decreased nutrient sensing, genomic instability, early senescence, epigenetic deterioration and of course, most importantly, NAD+ and ketone derivative glutaric acid depletion.
As a professional certified healthcare and a bio-hacker, involved in an aging dimension, been working with Harvard medical schools of epigenetics, I know how important can the Krebs Cycle stability be, having a pivotal role in modulating the major signaling pathways that influence the longevity of organisms. Thus, using a powerful precursor and intermediary metabolite activator for preventing age related diseases and premature deterioration is expected to be able to attenuate the process of aging and greatly ameliorate its effects.
Tackling aging is a challenge for any living organism, and longevity in human beings can be defined as a complex "phenotype". With the increase in human life expectancy, it has become an essential objective to preserve long-term health and maintain organic brain functionality and well-being during aging. Healthy aging is the result of the interaction between genes, stochastic processes (such as the unequal partition of cytoplasmatic components and cell-division asymmetry, among others and the environment, including modifiable lifestyle factors (such as diet and exercise.
Although a number of previous studies measured different pathways of different species, few of them determined the telomere shortening and other hallmarks rates, but in this regard, some studies found a correlation between NAD+ and Alpha Ketoglutarate degradation rates and species life spans, including previous work from one group in mice and humans, however, these studies did not compare side-by-side NAD degradation rates in phylogenetically distant species by using a single technique to measure NAD.
In a preprint article (not yet peer-reviewed) shared on Research square, Katayoshi and colleagues from the DHC, a corporation in Japan that sells skincare products, report the findings of a clinical trial testing the effects of AKG on humans. The results showed that AKG tends to reduce arterial stiffness in healthy middle-aged adults but without statistical significance. However, statistically significant reductions in arterial stiffness were observed in individuals with above-average weight and blood glucose levels. Furthermore, AKG was calculated to reverse blood vessel aging by two years.
Finally, the fact that the rate of obese animals increase due to their poor dietary choices, toxic spot on treatments, anti-helminthic medications increase, therefore, for those who are struggling with such kind of issues, particularly those adopting dogs from the shelters, it’s pivotal to involve a radical intervention along with the correct diet. That’s exactly what made us astonished reading the latest study published in Cell Proliferation, Dai and colleagues from Jilin University in China show that treating obese mice with the nicotinamide adenine dinucleotide (NAD+) precursor NMN and AKG together prevents DNA damage and enhances quality of oocytes. The China-based team goes on to show that the low body weights of the offspring produced by obese mothers can be restored by AKG. These findings suggest that obese females may utilize NMN and AKG to improve their oocyte quality and enhance their reproductive health.
Finally, autophagy, which is activated by caloric restriction and also the direct inhibition of TOR, is increased significantly in C. elegans given additional AKG. This means that AKG and TOR inhibition are increasing lifespan either via the same pathway or through independent/parallel pathways and mechanisms that ultimately converge on the same downstream target.
Further support for this has been shown in studies with starving yeast and bacteria and human post-exercise, where AKG levels are shown to be elevated. This increase is believed to be a starvation response, in this case anaplerotic gluconeogenesis, which activates glutamate-associated transaminases in the liver to generate carbon derived from amino acid catabolism.
This is consistent with the findings of the 2014 C. elegans study, which showed that AKG levels are elevated in starving worms but that AKG did not increase the lifespan of calorically restricted animals. This suggests that AKG is a key metabolite and player in the regulation of lifespan via starvation and caloric restriction. It also suggests that AKG is a molecular link between cellular energy generation and dietary restriction in the context of lifespan regulation.
In a healthy pet, the intestinal walls serve as a barrier, keeping foreign materials (such as bacteria, food allergens, toxins, etc.) out of the body’s circulation and tissues. When food is eaten, it passes through the esophagus, stomach, and intestines (undergoing various stages of digestion along the way), but only certain substances are actually absorbed by the intestines and permitted to enter the bloodstream.
In a pet with a leaky gut, the barrier function of the intestines is compromised. Therefore, substances that would normally pass through the intestines can instead cross the intestinal walls and enter the body’s circulation. Unfortunately, once again due to the toxins and endotoxins, this is becoming extraordinarily epidemic.
Dog telomere study: https://usir.
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