Resveratrol is an anti-estrogen Resveratrol, a compound in the skin of red grapes, has an anti-oestrogenic effect. 

According to a 2006 test-tube study by the Chinese University of Hong Kong, the effect is so strong that supplementation of high but not impossible doses can protect women against breast cancer. And it can help athletes to lower their estradiol levels, we add ourselves. Study The researchers experimented with the human breast cancer cell SK-BR-3 and the genetically altered MCF-7aro cell. MCF-7 is also originally a human breast cancer cell. The researchers used a version of that cell into which researchers had stuck extra genes, so that the cell started producing aromatase. Aromatase is the enzyme that turns testosterone and androstenedione into estradiol. The relationship between estradiol and cancer is twofold. Estradiol can turn into 4- and 16-hydroxy analogs, which can turn healthy cells into cancer cells. In addition, many breast cancer cells have receptors for estradiol. The higher the estradiol level, the faster the cells grow and the smaller the chance that the body's immune system can still clear them. The Chinese wondered whether resveratrol [structural formula above] could inhibit this process, thus reducing the chances of hormone-related cancer. They already knew that according to epidemiological studies, the small amounts of resveratrol that people ingest through grapes, peanuts and berries reduce the risk of breast cancer. [Eur J Cancer Prev. 2005 Apr;14(2):139-42.] Moreover, they knew that, in vitro at least, extracts from red grapes make aromatase less effective. [Cancer Res. 2003 Dec 1;63(23):8516-22.] 

 When the Chinese exposed SK-BR-3 cells to resveratrol, they saw that the aromatase became less active the higher the concentration of resveratrol. 

 

Resveratrol slowed the growth of MCF-7aro cells, which had also been exposed to testosterone. The higher the concentration of resveratrol, the greater the effect. Achievable The figures show that resveratrol will have a noticeable effect at a concentration of tens of micromoles. That is achievable if you use supplements, the researchers conclude from a study by the State University of New Jersey. [J Agric Food Chem. 2004 Feb 25;52(4):935-42.] In this, ingestion of 1 milligram resveratrol per kilogram of body weight in humans led to a resveratrol concentration of 40 micromole in the blood after one and a half hours. animal study If you say 'anti-oestrogen' to a strength athlete, he may involuntarily think 'more testosterone'. That association is also justified when it comes to resveratrol, according to an animal study from the Universitat de Barcelona from which we have stitched the figure from above. [J Nutr. 2005 Apr;135(4):757-60.] You can see what happens to the production of testosterone and sperm cells if you give mice 20 milligrams of resveratrol per kilogram of body weight for 90 days in a row. A conservative estimate of the human equivalent of that dose is 2 milligrams per kilogram of body weight. The health-promoting effect of resveratrol may be even greater than the Chinese study suggests. In cell studies, resveratol also inhibits the production of the genotoxic estradiol analogues [Cancer Prev Res (Phila). 2008 Jul;1(2):135-45.] and prevents damage to the genetic material. [Free Radic Biol Med. 2008 Jul 15;45(2):136-45.]