AKG increases lifespan

Ca-AKG increase lifespan Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in vari- ous metabolic and cellular pathways. As an antioxidant, AKG interferes in nitro- gen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few stud- ies published in the 1980s and 1990s in humans suggested the potential beneļ¬ts of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in humans.

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