AKG increases lifespan
Ca-AKG increase lifespan
Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in vari-
ous metabolic and cellular pathways. As an antioxidant, AKG interferes in nitro-
gen and ammonia balance, and affects epigenetic and immune regulation.
These pleiotropic functions of AKG suggest it may also extend human
healthspan. Recent studies in worms and mice support this concept. A few stud-
ies published in the 1980s and 1990s in humans suggested the potential beneļ¬ts
of AKG in muscle growth, wound healing, and in promoting faster recovery after
surgery. So far there are no recently published studies demonstrating the role of
AKG in treating aging and age-related diseases; hence, further clinical studies
are required to better understand the role of AKG in humans.
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